一、 基本信息
李学军，北京大学医学部药理学系教授，博士生导师，现兼任中国药理学会监事长、生化与分子药理专业委员会主任委员, 世界中联网络药理学会副会长等。曾任心血管药理专业委员会主任委员、国际科学联合会中国委员会委员、中国药理学会副理事长。并任3个国际杂志和国内20余个医药学相关杂志的副主编、常务编委和编委等。已独立培养博士生41人，硕士生7人。第一作者和责任作者文章85篇，主编专著《多靶点药物的研究与应用》、《表观遗传药理学》；主编本科生教材6部；副主编本科生及研究生教材5部，参编专著和教材80余部。以负责人主持科技部重大专项、国家自然科学基金重大国际合作项目、面上项目等十余项，以及主持卫生部、教育部、美国洛克菲勒基金等。为北京市教学名师，并曾获得五洲女子科技奖、第六届全国优秀科技工作者等。目前的研究方向为分子药理学，主要采用多组学和网络药理学等发现和确认药物靶点和新药，以及抗肿瘤、心血管系统和神经内分泌系统的药物药理学研究。
二、主持科学研究项目（在研项目）
1. 国家自然科学基金《肿瘤相关中性粒细胞和中性粒细胞弹性蛋白酶在肿瘤生长、转移中的作用及ZX-1201和西维来司钠的比较研究》。
2. 国家自然科学基金《BH3-only蛋白和自噬相关蛋白的表观和非表观遗传修饰及BH3拟似药的研究》。
三、讲授课程
1. 博士研究生：分子药理学与药物发现及技术（北大医学部）
2. 硕士研究生：高级药理学（365体育官方唯一入口）
3. 本科生课程：药理学进展（选修课，北大医学部）
四、代表性成果
1. 代表论文（通讯作者，2012 年以来发表的SCI 收录论文）
1. Tuohetaerbaike B, Zhang Y, Tian Y, Zhang NN, Kang J, Mao X, Zhang Y, Li X. Pancreas protective effects of Urolithin Aon type 2 diabetic mice induced by high fat and stre ptozotocin via regulating autophagy and AKT/mTOR signaling pathway. J Ethnopharma col. 2020 Mar 25;250:112479.
2. Zhang NN, Kang JS, Liu SS, Gu SM, Song ZP, Li FX, Wang LF, Yao L, Li T, Li LL, Wang Y, LiXJ, Mao XM. Flavanomarein inhibits high glucose -stimulated epithelial- mesenchymal transition in HK-2 cellsvia targeting spleen tyrosine kinase. Sci Rep. 2020; 16; 10(1):439-450
3. Wang Y, Fan S, Li X, Xiaokaiti Y, Pan Y, Tie L, Li X. The novel small molecular BH3 mimetics SM3 and its regulation of cell apoptosis and autophagy. Biochem Biophys Res Commun. 2019 Sep 10;517(1):15-22.
4. Maimaiti A, Aili A, Kuerban H, Li X. VDAC1 Mediated Anticancer Activity of Gallic Acid in Human Lung Adenocarcinoma A549 Cells. Anticancer Agents Med Chem. 2018；18(2): 255-262.
5. Tie Lu, Wang D, Shi Y, Li X. Aquaporins in Cardiovascular System. Adv Exp Med Biol. 2017;969:105-113.
6. Duan J, Xiaokaiti Y, Fan S, Pan Y, Li X, Li X. Direct interaction between caffeic acid phenethyl ester and human neutrophil elastase inhibits the growth and migration of PANC-1 cells. Oncol Rep. 2017 May;37(5):3019-3025.
7. Xin Li, Shengjun Fan, Xueyang Pan, Yilixiati Xiaokaiti, Jianhui Duan, Yundi Shi, Yan Pan, Lu Tie, Xin Wang, Yuhua Li, Xuejun Li. Nordihydroguaiaretic acid impairs prostate cancer cell migration and tumor metastasis by suppressing neuropilin 1. Oncotarget. 2016 Dec 27;7(52):86225-86238
8. Haopeng Yang, Shengjun Fan, Xin Li, Lu Tie, Min Ye, Xuejun Li. Bisdemethoxycurcumin exerts pro-apoptotic effects in human pancreatic adenocarcinoma cells through mitochondrial dysfunction and a GRP78 pathway. Oncotarget. 2016 Dec 13;7(50):83641-83656.
9. Shengjun Fan, Xin Li, Lu Tie, Yan Pan, Xuejun Li. KIAA0101 is associated with human renal cell carcinoma proliferation and migration induced by erythropoietin. Oncotarget, 2016 , 7 (12) :13520-13537.
10. Xiaokaiti Y, Wu H, Chen Y, Yang H, Duan J, Li X, Pan Y, Tie L, Zhang L, Li XJ. EGCG reverses human neutrophil elastase-induced migration in A549 cells by directly binding to HNE and by regulating α1-AT. Sci Rep.2015 Jul 16;5:11494.
11. Aikebaier Maimaiti, Kaisaier Abudoukeremu, Lu Tie, Yan Pan, Xuejun Li. MicroRNA expression profiling and functional annotation analysis of their targets associated with the malignant transformation of oral leukoplakia. Gene.2015 Mar 10;558(2):271-7
12. Yan Pan, Xin Li, Jianhui Duan, Lan Yuan, Shengjun Fan, Jingpu Fan, Yilixiati Xiaokaiti, Haopeng Yang, Yefan Wang, and Xuejun Li. Enoxaparin Sensitizes Human Non–Small-Cell Lung Carcinomas to Gefitinib by Inhibiting DOCK1 Expression, Vimentin Phosphorylation, and Akt Activation. Mol Pharmacol. March 2015, 87:378-390.
13. Hao F, Kang J, Cao Y, Fan S, Yang H, An Y, Pan Y, Tie L and Li X. Curcumin attenuates palmitate-induced apoptosis in MIN6 pancreatic β-cells through PI3K/Akt/FoxO1 and mitochondrial survival pathways. Apoptosis. 2015 Nov;20(11):1420-32.
14. Kui Chen, Yu An, Lu Tie, Yan Pan, and Xuejun Li. Curcumin Protects Neurons from Glutamate-Induced Excitotoxicity by Membrane Anchored AKAP79-PKA Interaction Network. Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 706207, 9 pages, 2015. doi:10.1155/2015/706207.
15. Shengjun Fan, Yan Xu,Xin Li, Lu Tie, Yan Pan and Xuejun Li. Opposite angiogenic outcome of curcumin against ischemia and Lewis lung cancer models: in silico, in vitro and in vivo studies. BBA - Molecular Basis of Disease. 2014; Sep. 1842 : 1742–1754
16. Shengjun Fan, Zhenyu Pan, Qiang Geng, Xin Li, Yefan Wang, Yu An, Yan Xu, Lu Tie, Yan Pan, Xuejun Li. Layered Signaling Regulatory Networks Analysis of Gene Expression Involved in Malignant Tumorigenesis of Non-Resolving Ulcerative Colitis via Integration of Cross-Study Microarray Profiles. PLoS ONE 2013 Jun 25;8(6):e67142. doi: 10.1371/ journal. pone. 0067142. Print 2013.
17. Yu An, Jian-zhao Zhang, Jing Han, Hao-peng Yang, Lu Tie, Xiao-yuan Yang, Yilixiati Xiaokaiti, Yan Pan, Xue-jun Li. Hypoxia-Inducible Factor-1α Dependent Pathways Mediate the Renoprotective Role of Acetazolamide Against Renal Ischemia-Reperfusion Injury. Cell Physiol Biochem 2013;32:1151-1166.
18. Tie Lu, An Yu, Han Jing, Xiao Yuan, Xiaokaiti Yilixiati, Fan Shengjun, Liu Shaoqiang, Chen Alex F., Li Xuejun. Genistein accelerates refractory wound healing by suppressing superoxide and FoxO1/iNOS pathway in type 1 diabetes. J Nutr Biochem. 2013; 24(1):88-96.
19. Yan Xu, Jingjie Zhang, Jing Han, Xueyang Pan, Yajun Cao, Hao Guo, Yan Pan, Yu An,Xuejun Li. Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of α1-antitrypsin in lung cancer. Molecular Oncology 2012, 6(4), 405–417
20. Jie Chen, Bing Liu, Jiayi Yuan, Jie Yang, Jingjie Zhang, Yu An, Lu Tie, Yan Pan, Xuejun Li. Atorvastatin Reduces Vascular Endothelial Growth Factor (VEGF) Expression in Human Non-small Cell Lung Carcinomas (NSCLCs) via Inhibition of Reactive Oxygen Species (ROS) Production. Molecular Oncology. Mol Oncol. 2012 Feb;6(1):62-72.
21. Jiabin Guo, Sue P. Duckles, John H. Weiss, Xuejun Li, Diana N. Krause. 17b-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen–glucose deprivation / reperfusion. Free Radical Biology and Medicine 2012:52 2151-2160.
22. Chen J, Lan T, Hou J, Zhang J, An Y, Tie L, Pan Y, Liu J, Li X. Atorvastatin sensitizes human non-small cell lung carcinomas to carboplatin via suppression of AKT activation and upregulation of TIMP-1. The International Journal of Biochemistry & Cell Biology(Int JBiochem Cell Biol. ) 2012 May;44(5):759-69.
23. Jing Han, Xue-Yang Pan, Yan Xu, Yuan Xiao, Yu An, Lu Tie, Yan Pan and Xue-Jun Li.Curcumin induces autophagy to protect vascular endothelial cell survival from oxidativestress damage. Autophagy 2012, 8:5, 1–14
24. Zhang J, An Y, Gao J, Han J, Pan X, LI XJ. Aquaporin-1 Translocation and Degradation Mediates the Water Transportation Mechanism of Acetazolamide. PLoS ONE 2012; 7(9):e45976. doi:10.1371/journal.pone.0045976.
25. Xiao Y, Li Y, Han J, Pan Y, Tie L, Li XJ. Transgelin 2 Participates in Lovastatin-Induced Anti-Angiogenic Effects in Endothelial Cells through a Phosphorylated Myosin Light Chain-Related Mechanism. PLoS ONE. 2012; 7(10): e46510. doi:10.1371/ journal.pone.0046510.
26. Tie Lu, Lu Ning, Pan Xueyang, Pan Yan, An Yu, Gao Junwei, Lin Yanhua, Yu Heming, Li Xuejun. Hypoxia-induced up-regulation of aquaporin-1 protein in prostate cancer cells in ap38-dependent manner. Cell Physiol Biochem. 2012;29:269-280.
27. Jie Chen, Jincai Hou, Jingjie Zhang, Yu An, Xiaojie Zhang, Liling Yue, Jicheng Liu, Xuejun Li Atorvastatin synergizes with IFN-γ in treating human non-small cell lung carcinomas via potent inhibition of RhoA activity. Eur J Pharmacol. 2012 May 5;682(1-3):161-70
28. Pan XY, Guo H, Han J, Hao F, An Y, Xu Y, Xiaokaiti Y, Pan Y, Li XJ. Ginsenoside Rg3 attenuates cell migration via inhibition of aquaporin 1 expression in PC-3M prostate cancer cells. Eur J Pharmacol. 2012 May 15;683(1-3):27-34.
29. Yan PAN, Li-jun ZHONG, Hong ZHOU, Xin WANG, Kui CHEN, Hao-peng YANG, Yilixiati XIAOKAITI, Aikebaier MAIMAITI, Ling JIANG, Xue-jun LI. Roles of vimentin and 14-3-3 zeta/delta in the inhibitory effects of Heparin on PC-3M cell proliferation and B16-F10-luc-G5 Cells metastasis. Acta Pharmacologica Sinica 2012:1–11.
30. Tie Lu, Yang Hongqin, An Yu, Liu Shaoqiang, Han Jing, Xu Yan, Hu Min, Li Weidong, Chen Alex F., Lin Zhibin, Li Xuejun. Ganoderma lucidum polysaccharide accelerates refractory wound healing by inhibition of mitochondrial oxidative stress in type 1 diabetes. Cell Physiol Biochem. 2012;29:583-594.
31. Fan S, Geng Q, Pan Z, Li X, Tie L, Pan Y, Li X. Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec
10;6(1):152
2. 发明专利
[1] 李学军等，AD23作为BH3拟似药对小细胞肺癌的抑制作用及与组蛋白去乙酰化酶抑制剂协同作用，2021年7月公开，申请号或专利号：202110 262844.3
[2] 李学军等. 用于治疗抑郁症的复方制剂. 专利号：ZL201010508418.5 (2012年2月22日授权) IPC：【国际主分类号】：A61K45/00
[3] 李学军等.化合物1-[5-（丁基）-1，3，4-噻二唑-2-基-3-（3-氯苯基）]脲的用途，专利号：ZL201010508432.5 (2012年5月23日授权) IPC:【国际主分类号】A61K31/433
[4] 李学军等碳酸酐酶抑制剂的抗生育作用，批准号专利号：ZL 00109104.2 (2003年11月12日)
3. 代表著作（列出主编的专著，参编以及主编和参编的教材从略）
[1]《表观遗传药理学》, 科学技术文献出版社, 2019年9月，主编
[2]《多靶点药物的研究与应用》, 人卫出版社, 2011年11月，主编
五、联系方式
1. 联系电话（办公室）：010-82802863（北京）, 0993-2057003（石河子）
2. E-mail：xjli@bjmu.edu.cn
3. 通讯地址：新疆维吾尔自治区石河子市，北2路59号，365体育官方唯一入口医学校区，365体育官方唯一入口
4. 邮编：832002
